预期焦虑的神经解剖相关物
E M Reiman1, M J Fusselman, P T Fox
1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
概括
预期焦虑是一种正常的情绪,显示大脑极的血液流量增加. 这些发现将极活动与正常和病态焦虑状态联系起来.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 焦虑是一种常见的人类情绪,具有复杂的神经生物学基础.
- 了解焦虑的神经基础对于开发有效治疗方法至关重要.
- 之前的研究已经涉及到各种大脑区域在焦虑反应.
研究的目的:
- 为了研究正常预期焦虑的神经解剖相关性.
- 为了确定在焦虑期间显示神经元活动变化的大脑区域.
- 探索特定大脑区域在正常和病态焦虑中的作用.
主要方法:
- 使用正子发射断层扫描 (PET) 来测量区域大脑血流 (rCBF).
- 在预测痛苦的电击之前,期间和之后,对健康志愿者进行了评估rCBF.
- 血流的相关变化与主观的焦虑体验.
主要成果:
- 在预期焦虑期间,在双边极观察到血液流量的显著增加.
- 这些极区域以前与恐慌症患者的乳酸诱导焦虑有关.
- 证明了时间极活动和焦虑的经验之间的联系.
结论:
- 极是关键的大脑区域,参与正常人类焦虑的神经生物学.
- 研究结果表明,正常预期性焦虑和病理性焦虑状态的共同神经解剖基质.
- 突出时间极在适应性和不适应性焦虑反应中的作用.
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