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Updated: Mar 12, 2026

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一种生物活性粉体的新设计

Rodrigo Gallardo1,2, Meine Ramakers1,2, Frederik De Smet1,2

  • 1VIB Switch Laboratory, Leuven, Belgium.

Science (New York, N.Y.)
|November 16, 2016
PubMed
概括

合成的粉样蛋白可以导致细胞死亡,但只有当目标蛋白对细胞存活至关重要时. 这项研究揭示了粉样蛋白毒性是蛋白质特异性和上下文依赖的,而不仅仅是由于蛋白质聚合.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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