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寨卡病毒导致小鼠丸受损,导致雄性不育

Wenqiang Ma¹, Shihua Li², Shuoqian Ma¹

¹State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

|November 26, 2016

概括

寨卡病毒感染雄性小鼠的丸,导致炎症和损伤. 这种在精液中的持续存在可能导致男性不孕.

科学领域:

病毒学
免疫学
生殖生物学

背景情况:

已知寨卡病毒 (ZIKV) 存在于人体精液中,这是黄病毒中独特的特征.
尚不完全了解ZIKV对男性生殖器官的影响以及可能导致不孕症等长期后果.

研究的目的:

在小鼠模型中研究ZIKV感染对雄性生殖系统的影响.
鉴定丸和副内易受ZIKV感染的特定细胞类型并促进免疫反应.

主要方法:

成年雄性小鼠感染了ZIKV.
在感染后60天,对丸,上皮,前列腺和精液囊进行了细胞病理分析.
用免疫组织化学和细胞因子/ 化学因子分析来评估不同丸细胞类型的先天免疫反应.

主要成果:

ZIKV感染导致丸和上皮炎症,但不是前列腺或精液囊泡.
在感染后60天观察到明显的丸损伤.
莱迪格细胞,塞尔托利细胞和外皮上皮细胞通过促炎性细胞因子/化学因子产生先天性免疫反应.
周管细胞和精子细胞的细胞因子产生有限,这表明它们可能充当病毒储存器.

结论:

在小鼠中,ZIKV感染会引起严重的炎症和丸损伤.
特定的丸细胞群是易受ZIKV感染的,可能充当病毒储存库.
这些发现表明ZIKV感染与男性生殖系统损伤之间存在关联,可能导致不孕.

关键词:

在 AXL 寨卡病毒男性不孕症脊髓炎 - 脊髓炎

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