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Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
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自闭症中 lncRNA,拼接和区域基因表达模式的全基因组变化

Neelroop N Parikshak1,2, Vivek Swarup1,2, T Grant Belgard1,2

  • 1Center for Autism Research and Treatment and Program in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA.

Nature
|December 6, 2016
PubMed
概括

在自闭症谱系障碍 (ASD) 中,遗传因素汇聚在共同的途径上. 这项研究揭示了非编码RNA的失调,改变了拼接,并减少了ASD大脑的区域基因表达差异.

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