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Updated: Mar 10, 2026

A Novel Saturation Mutagenesis Approach: Single Step Characterization of Regulatory Protein Binding Sites in RNA Using Phosphorothioates
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Published on: August 21, 2018

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m6A增强了Sxl替代的mRNA前拼接,以进行强大的Drosophila性别确定

Irmgard U Haussmann1,2, Zsuzsanna Bodi3, Eugenio Sanchez-Moran1

  • 1School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Nature
|December 6, 2016
PubMed
概括

在Drosophila中,N-甲基氨酸 (m6A) RNA修饰对于女性特异性Sxl基因的替代拼接至关重要. 这种古老的机制涉及m6A读者蛋白YT521-B,调节基因表达并防止女性的剂量补偿.

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