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Updated: Mar 10, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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CCR9受体的细胞内性对抗作用

Christine Oswald1, Mathieu Rappas1, James Kean1

  • 1Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.

Nature
|December 8, 2016
PubMed
概括

与vercirnon结合的CC化基因受体9 (CCR9) 的晶体结构显示出一种全抗体机制. 这一发现解释了以前的药物疗效问题,并为化学因子受体药物设计提供了新的目标.

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