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对老年人左心室扩张功能的当代评估:社区中的动脉样硬化风险研究
Amil M Shah1, Brian Claggett2, Dalane Kitzman2
1From Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (A.M.S., B.C., T.B.-S., S.C., S.D.S.); Wake Forest University School of Medicine, Winston-Salem, NC (D.K.); Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark (T.B.-S., J.S.J.); Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (K.M.); Cardiovascular Division, (S.K.) and Division of Epidemiology and Community Health, School of Public Health (A.R.F.), University of Minnesota, Minneapolis; Divisions of Geriatrics and Neurology, University of Mississippi Medical Center, Jackson (T.H.M.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.D.W.); and University of North Carolina Gillings School of Global Public Health, Chapel Hill (G.H.). ashah11@partners.org.
在老年人中,透气功能的新参考范围显示,下部组织多普勒成像
科学领域:
- 心脏病学
- 老年学
- 心声检查
背景情况:
- 已发现与年龄相关的左心室扩张功能变化,但对老年人的参考范围有限.
- 目前对透析功能的指导方针可能不准确地反映人口老龄化.
- 在老年人中,扩张功能,心力衰竭 (HF) 生物标志物和发生性HF之间的关联需要进一步描述.
研究的目的:
- 在老年人中建立特定年龄的透气功能的基准范围.
- 评估这些措施对发生心力衰竭 (HF) 和死亡的预后价值.
- 确定透析功能的与N终端亲脑尿素 (NT-proBNP) 的关联.
主要方法:
- 对ARIC研究中的5801名老年人 (年龄在67- 90岁之间) 的分析.
- 组织多普勒成像 (TDI) e',E/e'和左心房大小的评估.
- 在没有心血管疾病的子组中使用量子回归来确定性别特异性的第10百分位和第90百分位极限.
主要成果:
- 基于ARIC的TDI e'的基准值低于目前的指导切割点.
- 扩张度与NT-proBNP和发生的HF或死亡有关.
- 基于年龄的限制改善了与基于指导方针的切断点相比,对发生的HF的风险歧视.
- 复制了哥本哈根城市心脏研究的结果.
结论:
- 左心室纵向放松速度随着健康的衰老而下降,并且往往是良性的预后.
- 使用基于年龄的规范值可以更好地预测老年人发生肺炎的风险.
- 新的参考范围改善了老年人群中HF风险的分层.
相关概念视频
Assessment of the Cardiovascular System IV: Auscultation
Normal Heart Sounds
S1 (First Heart Sound)-
S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
S2 (Second Heart Sound)-
S2 is made by the closure of the aortic and pulmonic valves (semilunar valves), marking the end of the systole.
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Cardiac Catheterization III: Left Heart Catheterization
Mitral Stenosis II: Clinical features and Diagnostic Tests

