为预防患有湿疹的高风险婴儿的卵子过敏 (PETIT) 的两步引入:随机,双盲,安慰剂对照试验
Osamu Natsume1, Shigenori Kabashima2, Junko Nakazato3
1Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development; Okura, Setagaya-Ku, Tokyo, Japan; Division of Pediatrics, Hamamatsu University School of Medicine; Handayama, Higashiku, Hamamatsu, Shizuoka, Japan.
Lancet (London, England)
|December 13, 2016
概括
及早引入加热蛋,加上治疗湿疹,可以有效地预防高风险婴儿的蛋过敏. 这种策略提供了一种减少食物过敏的安全方法.
科学领域:
- 过敏和免疫学
- 儿童医学
- 临床研究
背景情况:
- 越来越多的证据表明早食可以预防食物过敏.
- 然而,过敏反应对早期食品引入策略构成挑战.
- 这项研究旨在预防患有湿疹的婴儿对蛋过敏.
研究的目的:
- 调查早期逐步引入蛋是否可以预防患有湿疹的婴儿产生蛋过敏.
- 评估这种干预措施的安全性和有效性.
主要方法:
- 这是一项随机,双盲,安慰剂对照试验,涉及147名患有湿疹的婴儿 (4-5个月).
- 婴儿从6个月到12个月每天接受加热卵粉或安慰剂.
- 在整个研究过程中,一直在治疗侵袭性湿疹.
主要成果:
- 与安慰剂组相比,12个月后的蛋过敏显著降低 (8%).
- 蛋过敏的风险比为0. 221 (p=0. 0001).
- 卵组的住院病例较高,但急性过敏事件在各组之间相似.
结论:
- 在高风险的婴儿中,逐步引入加热的蛋与积极的湿疹治疗是安全有效的预防蛋过敏.
- 这种方法有助于缓解食物过敏的增加.
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