Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...
Neurons as Communicators of the Brain01:22

Neurons as Communicators of the Brain

Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A spatially-explicit watershed model for tracking nitrogen fate and transport by integration of biogeochemistry and hydrology.

Water research·2026
Same author

Role of enteral nutrition in the clinical care, management, and quality of life of patients with inflammatory bowel disease.

Frontiers in nutrition·2026
Same author

Pituitary Stalk Lesion Sampling by Transsphenoidal Posterior Lobe Biopsy: A Case Series.

Journal of neurological surgery. Part B, Skull base·2026
Same author

Unified Modulation Matrix-Based Shared Control for Teleoperated Multi-Robot Formation and Obstacle Avoidance.

Sensors (Basel, Switzerland)·2026
Same author

A Single-Cell Atlas of Pan-Cancer Liver Metastasis Reveals Dynamic Cellular Programs Driving Metastatic Progression and Immune Modulation.

Research (Washington, D.C.)·2026
Same author

Author Correction: Natural behaviour is learned through dopamine-mediated reinforcement.

Nature·2026
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
查看所有相关文章

相关实验视频

Updated: May 10, 2026

A Lightweight, Headphones-based System for Manipulating Auditory Feedback in Songbirds
10:13

A Lightweight, Headphones-based System for Manipulating Auditory Feedback in Songbirds

Published on: November 26, 2012

14.8K

多巴胺神经元编码唱歌鸟的表现错误

Vikram Gadagkar1, Pavel A Puzerey1, Ruidong Chen1

  • 1Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA.

Science (New York, N.Y.)
|December 13, 2016
PubMed
概括
此摘要是机器生成的。

当表现与内部目标不匹配时, 多巴胺神经元在唱歌鸟中发出错误信号. 这揭示了大脑如何评估未受外部奖励驱动的学习行为,

更多相关视频

Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning
11:20

Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning

Published on: June 2, 2014

12.5K
Operant Conditioning Task to Measure Song Preference in Zebra Finches
06:40

Operant Conditioning Task to Measure Song Preference in Zebra Finches

Published on: December 26, 2019

7.0K

相关实验视频

Last Updated: May 10, 2026

A Lightweight, Headphones-based System for Manipulating Auditory Feedback in Songbirds
10:13

A Lightweight, Headphones-based System for Manipulating Auditory Feedback in Songbirds

Published on: November 26, 2012

14.8K
Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning
11:20

Recording Single Neurons' Action Potentials from Freely Moving Pigeons Across Three Stages of Learning

Published on: June 2, 2014

12.5K
Operant Conditioning Task to Measure Song Preference in Zebra Finches
06:40

Operant Conditioning Task to Measure Song Preference in Zebra Finches

Published on: December 26, 2019

7.0K

科学领域:

  • 神经科学
  • 动物的行为
  • 听觉学习

背景情况:

  • 对内部目标进行评估的神经机制尚不清楚.
  • 多巴胺在学习中的作用通常与奖励预测错误有关.

研究的目的:

  • 研究多巴胺神经元在评估基于内部目标的学习行为中的作用.
  • 了解多巴胺如何在表现偏离预期结果时发出错误信号.

主要方法:

  • 在唱歌的斑马中记录了多巴胺神经元活动.
  • 通过扭曲的听觉反来操纵感知歌曲质量.
  • 相关的多巴胺活动与特定的歌曲元素和听觉反.

主要成果:

  • 扭曲音节后多巴胺活性下降 (结果比预期更差).
  • 当预测的扭曲不发生时,多巴胺活性增加 (比预测更好的结果).
  • 多巴胺错误信号的大小随着扭曲的可能性而变化.

结论:

  • 不仅仅是奖励预测错误.
  • 通过将表现与内部目标相匹配来学习行为,
  • 这些发现扩大了多巴胺在学习和行为评估中的已知功能.