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相关概念视频

RNA Structure01:19

RNA Structure

8.0K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
8.0K
RNA Structure01:23

RNA Structure

79.8K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.8K
Riboswitches01:56

Riboswitches

10.0K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
10.0K
RNA Stability01:53

RNA Stability

36.0K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
36.0K
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

979
Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
979
Types of RNA01:20

Types of RNA

10.2K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
10.2K
这页已由机器翻译。其他页面可能仍然显示为英文。View in English
  1. 首页
  2. 研究领域
  3. 化学科学
  4. 有机化学
  5. 自由基化学
  6. 小细节很重要:rna中的2'-基作为构成交换机
  1. 首页
  2. 研究领域
  3. 化学科学
  4. 有机化学
  5. 自由基化学
  6. 小细节很重要:rna中的2'-基作为构成交换机

相关实验视频

Monitoring Equilibrium Changes in RNA Structure by 'Peroxidative' and 'Oxidative' Hydroxyl Radical Footprinting
13:41

Monitoring Equilibrium Changes in RNA Structure by 'Peroxidative' and 'Oxidative' Hydroxyl Radical Footprinting

Published on: October 17, 2011

14.7K

小细节很重要:RNA中的2'-基作为构成交换机

Leonardo Darré1,2, Ivan Ivani1,2, Pablo D Dans1,2

  • 1Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology , 08028 Barcelona, Spain.

Journal of the American Chemical Society
|December 14, 2016

在PubMed 上查看摘要

概括
此摘要是机器生成的。

核糖核酸 (RNA) 中的2'OH组影响其3D结构和功能. 蛋白质可以改变2'OH结构以控制RNA结构,影响蛋白质-RNA识别.

更多相关视频

Nanomanipulation of Single RNA Molecules by Optical Tweezers
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Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

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DNAzyme-dependent Analysis of rRNA 2’-O-Methylation
09:12

DNAzyme-dependent Analysis of rRNA 2’-O-Methylation

Published on: September 16, 2019

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相关实验视频

Monitoring Equilibrium Changes in RNA Structure by 'Peroxidative' and 'Oxidative' Hydroxyl Radical Footprinting
13:41

Monitoring Equilibrium Changes in RNA Structure by 'Peroxidative' and 'Oxidative' Hydroxyl Radical Footprinting

Published on: October 17, 2011

14.7K
Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

15.5K
DNAzyme-dependent Analysis of rRNA 2’-O-Methylation
09:12

DNAzyme-dependent Analysis of rRNA 2’-O-Methylation

Published on: September 16, 2019

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科学领域:

  • 生物化学
  • 分子生物学
  • 结构生物学

背景情况:

  • 核糖核酸 (RNA) 具有复杂的3D结构,对各种细胞功能至关重要.
  • RNA中的2'基 (2'OH) 组对其结构灵活性和相互作用网络产生重大影响.
  • 了解RNA的结构动态是解读其功能多样性的关键.

研究的目的:

  • 研究2'OH组在调节RNA结构中的作用.
  • 探索蛋白质如何调节2'OH结构及其对RNA糖的作用.
  • 阐明2'OH组作为蛋白质-RNA识别中的分子开关的功能.

主要方法:

  • 对RNA结构的数据库分析.
  • 广泛的分子动力学 (MD) 模拟.
  • 量子力学 (QM) 和量子力学/分子力学 (QM/MM) 混合模拟.

主要成果:

  • 直接证据证明2'OH构成对RNA糖的显著影响.
  • 计算显示蛋白质可以改变2'OH构造,诱导糖反.
  • 确定2'OH组是形成生物活性RNA结构的关键因素.

结论:

  • 2'OH 组在蛋白质-RNA 相互作用中起到关键分子开关的作用.
  • 蛋白质对2'OH构造的调节是控制RNA结构和功能的机制.
  • 这项研究提供了特定蛋白质-RNA识别的结构基础.