一个Janus化剂使生物化学反应敏捷的MRI对比具有特殊的动态范围
Eric M Gale1, Chloe M Jones1, Ian Ramsay1
1The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School , 149 Thirteenth Street, Suite 2301, Charlestown, Massachusetts 02129, United States.
Journal of the American Chemical Society
|December 15, 2016
概括
研究人员开发了一种基于 (Mn) 的新型MRI对比剂,具有"Janus"连接体. 这种药物通过在Mn3+和Mn2+氧化状态之间切换,以响应生物信号,表现出9倍的放松性变化.
科学领域:
- 生物化学 生物化学
- 医疗成像医学成像
- 材料科学 材料科学 材料科学
背景情况:
- 目前的MRI对比剂在响应能力上有局限性.
- 开发能够根据生物环境改变性质的药剂至关重要.
研究的目的:
- 介绍一种新的生化反应敏捷的基于 (Mn) 的MRI对比剂.
- 通过氧化状态切换来证明放松性的显著变化.
主要方法:
- 设计了一种"Janus"连接体,能够异体化,有利于Mn3+或Mn2+结合.
- 研究了Mn3+和Mn2+复合体在生物条件下的稳定性.
- 利用过氧化酶活性进行氧化和L-半氨酸进行还原到介质相互转换.
主要成果:
- 通过在Mn3+和Mn2+氧化状态之间切换,实现了放松度的9倍变化.
- 在生物环境中,Janus配体支持稳定的Mn3+和Mn2+复合体.
- 通过生物因素调解的氧化状态的快速相互转换.
结论:
- 贾努斯系统代表了设计生化反应敏捷的MRI对比剂的新范式.
- 这种方法使得MRI对比剂能够动态报告生物活性.
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