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计算机断层成像在缺血性中风中对丁氏酶的反应的影响:对2项随机对照试验的分析

Andrew Bivard¹, Xuya Huang², Patrick McElduff²

¹From Department of Neurology, John Hunter Hospital, University of Newcastle, Australia (A.B., P.M., C.R.L., M.W.D.); Institute of Neuroscience and Psychology, University of Glasgow, Queen Elizabeth University Hospital, Scotland, UK (X.H., B.K.C., D.K., F.C.M., I.F., K.W.M.); Department of Medicine and Neurology, Royal Melbourne Hospital (B.C.V.C., S.M.D.), and The Florey Institute of Neuroscience and Mental Health (C.F.B., G.A.D.), University of Melbourne, Australia; and Department of Neurology, Eastern Health Clinical School, Monash University, Melbourne, Australia (C.F.B.). andrew.bivard@hotmail.com.

|December 15, 2016

概括

与阿尔特相比,特内克对急性缺血性中风患者的治疗结果有所改善,早期临床改善和晚期康复更好. 这表明在特定的患者小组中存在潜在的益处.

科学领域:

神经学
心血管医学
放射学

背景情况:

急性缺血性中风的治疗包括再注血治疗.
甲和甲是常用的血栓消毒剂.
之前的试验给出了对抗性结果.

研究的目的:

在急性缺血性中风患者中,评估甲与甲.
通过高级成像检测发现的目标不匹配的患者的功能结果是否有改善.
根据临床和成像结果评估安全性和有效性.

主要方法:

来自两项临床试验的数据汇总,比较了甲和高甲.
评估国家卫生研究院中风量表变化和修改的兰金量表得分.
使用计算机断层扫描输液来定义目标不匹配标准.
分析的患者分组符合目标不匹配标准.

主要成果:

甲显示出较大的早期临床改善和较少的帕伦基马血瘤.
综合分析并没有显示用甲显著改善患者的治疗结果.
在目标不匹配小组中,丁烯基显著改善了早期的临床改善和晚期的恢复.

结论:

与阿尔特相比,坦克特可能具有更好的疗效和安全性.
在计算机断层扫描输液定义目标不匹配的患者中,基的益处似乎被夸大了.
通过先进的成像识别目标不匹配,可以指导治疗选择.

关键词:

输液成像脑中风,缺血症血栓溶解疗法

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