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通过脂肪酸受体CD36向转移启动细胞

Gloria Pascual¹, Alexandra Avgustinova¹, Stefania Mejetta²

¹Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.

|December 16, 2016

概括

科学家在口腔癌中发现了依赖饮食脂质的转移细胞. 阻断脂肪酸受体CD36有效抑制了小鼠模型中的癌症扩散,提供了潜在的新疗法.

科学领域:

癌症学
癌症生物学
代谢过程

背景情况:

癌症治疗中的一个关键挑战, 引发转移的细胞的身份仍然很大程度上是未知的.
了解这些细胞对于开发有效的抗转移疗法至关重要.

研究的目的:

鉴定和描述导致人类口腔癌转移的特定细胞群.
研究脂质代谢和CD36受体在转移开始和进展中的作用.

主要方法:

在人类口腔癌中CD44亮细胞的特征.
在服用棕酸或高脂肪饮食后评估转移潜力.
在正位鼠模型中使用 CD36 中和抗体抑制转移.
患者预后的CD36+转移细胞的临床相关性分析.

主要成果:

一个CD44bright细胞亚群被确定为转移启动细胞 (MICs),其特征是高CD36表达和脂质代谢基因.
饮食中的脂质,特别是棕酸,以CD36依赖的方式增强了CD36+MIC的转移潜力.
在临床前癌症模型中,中和抗体的CD36阻断显著抑制了转移,没有观察到副作用.
临床数据显示CD36+MIC与各种癌症类型的不良预后之间存在相关性.

结论:

转移启动细胞对于其转移前的功能至关依赖于食脂质.
向CD36是抑制多种癌症转移的有希望的治疗策略.
阻止CD36提供了一种潜在的无副作用的方法来对抗癌症的传播.

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