乳腺癌中的早期传播种子转移
Hedayatollah Hosseini1, Milan M S Obradović1, Martin Hoffmann2
1Experimental Medicine and Therapy Research, University of Regensburg, 93053 Regensburg, Germany.
Nature
|December 16, 2016
概括
孕激素信号驱动早期癌细胞迁移和转移,在晚期瘤中转向扩散. 大多数转移来自早期扩散的细胞,突显了早期瘤扩散的重要性.
科学领域:
- 癌症学
- 分子生物学
- 癌症研究
背景情况:
- 转移性扩散是癌症的标志,通常发生在瘤发育的早期.
- 导致早期转移的机制尚不完全理解.
研究的目的:
- 在HER2驱动的乳腺癌模型中研究早期转移的机制.
- 阐明孕激素信号在瘤进展过程中的癌细胞迁移和增殖中的作用.
主要方法:
- 使用HER2驱动的小鼠乳腺癌模型.
- 分析了孕激素诱导的信号传递,癌细胞迁移,增殖和干性特征.
- 研究了HER2表达,瘤细胞密度和微RNA在细胞行为调节中的作用.
- 对人类扩散癌细胞和原发性瘤进行了型和表型分析.
主要成果:
- 孕激素信号触发了早期病变的迁移和晚期瘤的扩散.
- 从迁移到增殖的转换是由HER2表达,瘤密度和微RNA介导的孕激素受体下调调节的.
- 早期,低密度的瘤细胞表现出更高的干度,迁移和转移潜力.
- 至少80%的转移来自早期扩散的癌细胞.
- 这些发现在人类扩散癌细胞和原发性瘤中得到证实.
结论:
- 早期扩散的癌细胞是转移的主要来源.
- 孕激素在癌症进展中起着双重作用,促进早期迁移和晚期扩散.
- 了解这些早期转移机制对于开发有效的癌症疗法至关重要.
相关概念视频
02:30Metastasis
6.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.7K
02:07Tumor Progression
7.7K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.7K