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使用光激活光滴对细胞内相变的时空控制

Yongdae Shin1, Joel Berry2, Nicole Pannucci3

  • 1Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.

Cell
|January 3, 2017
PubMed
概括

科学家开发了一种新的光遗传工具, 用光控制细胞相变. 这种系统使研究人员能够研究类似液体的蛋白质凝聚物的形成和可逆性以及它们与疾病的联系.

关键词:
结合RNA的蛋白质聚合方式流体体制剂细胞内凝结物固有无序的蛋白质液态相隔离没有膜的器官视觉遗传学核蛋白体

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Protein Dynamics in Living Cells01:19

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Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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