在隔离的子心脏中,通过子宫外激活产生的心肌再极化缓慢而持久的调节. 这是关于心脏"记忆"的证据
A Costard-Jäckle1, B Goetsch, M Antz
1Cardiology Division, Stanford University School of Medicine, California.
Circulation
|November 1, 1989
概括
长时间的心室节奏通过改变激活序列来改变心脏再极化. 这项研究表明,步调如何影响动作潜力的持续时间,并与时间的反极化同步.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 计算生物学 计算生物学
背景情况:
- 长时间的心室节奏会导致持续的T波极性变化.
- 了解如何改变激活序列影响心室再极化至关重要.
研究的目的:
- 调查激活序列长时间变化的对心室再极化影响.
- 为了检查不同节奏条件下动作潜能持续时间 (APD) 和激活时间 (AT) 之间的关系.
主要方法:
- 研究了9个孤立的兰登多夫透的子心脏.
- 使用接触电极探针绘制心表单相作用电位的映射.
- 在心房和心室节拍过程中使用线性回归分析APD和AT.
主要成果:
- 最初,心房节奏显示了APD和AT之间的反向关系 (较早的激活以后再极化).
- 心室节奏扰乱了这种反向相关性,随着持续的节奏,这种反向相关性逐渐重新出现.
- 随后的心房节奏也扰乱了相关性,但随着时间的推移,它被恢复了.
结论:
- 长时间的心室节奏改变了激活时间和动作潜能持续时间之间的关系.
- 在AT和APD之间的反向相关性促进同步复极化时间.
- 这些发现为改变心脏激活序列的电生理学适应提供了洞察力.
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