由于轻度低温而导致的缩和腹性左心室功能障碍
P S Greene1, D E Cameron, M L Mohlala
1Division of Cardiac Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
Circulation
|November 1, 1989
概括
轻度低温显著损害心脏病患者的左心室 (LV) 收缩性和舒张功能. 这项研究表明,即使在温和的低温温度下,区域工作减少和放松时间延长.
科学领域:
- 心血管生理学心血管生理学
- 心脏外科手术 心脏外科手术
背景情况:
- 手术后的心脏病患者经常经历轻度低温.
- 轻度低温对左心室 (LV) 收缩性的影响尚不清楚.
研究的目的:
- 为了研究轻度低温对LV收缩性和扩张功能的影响.
- 量化不同温度下区域工作和压力衰减的变化.
主要方法:
- 六只猪接受了部分右心室旁路术,心率控制.
- 心肌温度被操纵在34°C和38°C之间.
- 用sonomicrometer晶体测量LV区域工作和异体体松时间常数.
主要成果:
- 区域性工作显著下降,从38°C的85.1%降至34°C的31.9%.
- 随着温度的下降,LV压力衰变时间常数从44.8ms延长到61.6ms.
- 这些发现表明 LV 收缩性和腹功能明显下降.
结论:
- 轻度低温,即使在心脏手术后临床上遇到的水平,也显着抑制了LV收缩性.
- 低温会对左心室的缩和放缩功能产生负面影响.
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