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局部性前列腺癌的基因组特征

Michael Fraser¹, Veronica Y Sabelnykova², Takafumi N Yamaguchi²

¹Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

|January 10, 2017

概括

基因组分析揭示了局部前列腺癌的非编码异常和大规模重组. 这些异常的新型分子特征比现有的生物标志物更好地预测复发.

科学领域:

基因组学
癌症学
分子生物学

背景情况:

前列腺瘤治疗的反应有显著的变化,目前的预后因素对此的解释有限.
了解局部性前列腺癌的基因组环境对于改善患者的治疗结果至关重要.

研究的目的:

研究具有相似临床风险的局部前列腺瘤的基因组异质性.
识别新的分子异常及其在前列腺癌复发中的预后意义.

主要方法:

分别对200个和277个局部前列腺瘤进行全基因组和全外基因组测序.
在部分样本上进行了RNA和甲基化分析.
分析非编码异常,基因组重组和超突变事件.

主要成果:

与转移性疾病相比,局部前列腺瘤缺乏可操作的单核酸变异.
经常出现的非编码异常,大规模的基因组重组和转录抑制逆转.
包括DNA甲基化事件在内的众多分子异常是复发的预后,超过了已知的生物标志物.

结论:

一种结合多个分子异常的新型基因组特征是前列腺癌复发的有力预测因素.
基因组分析可以识别可能受益于强化治疗策略的侵袭性局部前列腺癌.
通过加强基因组侵袭性局部性前列腺癌的治疗,可以提高治愈率.

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