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阿斯加德古生物揭示了真核细胞复杂性的起源
Katarzyna Zaremba-Niedzwiedzka1, Eva F Caceres1, Jimmy H Saw1
1Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, SE-75123 Uppsala, Sweden.
Nature
|January 13, 2017
概括
亚斯加德超级组,包括洛基阿基奥塔,揭示了具有真核特征的古生物. 这些发现表明,在共生之前,古细胞宿主细胞具有真核细胞复杂性的关键组成部分.
科学领域:
- 微生物学
- 细胞生物学
- 进化生物学
背景情况:
- 细胞的起源及其细胞复杂性是一个重要的生物学难题.
- 目前的假设提出了一个古老宿主和一个alphaproteobacterial内生体之间的合并.
- 洛基阿基奥塔是一种古生物类,表现出众多的真核细胞特征,表明与宿主细胞的联系.
研究的目的:
- 研究真核细胞复杂性的进化起源.
- 识别与真核生物共享特征的考古遗传系.
- 扩大对考古基因组及其蛋白质库的理解.
主要方法:
- 基因组分析以确定进化关系.
- 对未培养的古生物进行基因组测序和分析.
- 在古生物和真核生物之间识别和比较蛋白质同类.
主要成果:
- 描述了包括洛基,托尔,奥丁和海姆达拉科塔的"阿斯加德"超级类.
- 在基因组学研究中,阿斯加德古生物与真核生物有着强烈的关联.
- 阿斯加德古生物的基因组,特别是Thorarchaeota,包含许多以前被认为是真核生物特有的蛋白质,包括膜贩运机械的组件.
结论:
- 阿斯加德古生物拥有大量"真核生物特异性"蛋白质.
- 在内共生事件发生之前,古细胞宿主细胞可能包含了许多真核细胞复杂性的重要组成部分.
- 这一发现完善了我们对古生物对真核细胞进化的贡献的理解.
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