在灵长类动物中用于回顾的元记忆的因果神经网络
Kentaro Miyamoto1, Takahiro Osada1,2, Rieko Setsuie1
1Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
概括
这项研究揭示了监测近期和远期记忆的不同大脑区域. 关闭这些区域可选择性地影响记忆的判断,
科学领域:
- 神经科学
- 认知神经科学
- 决策神经科学
背景情况:
- 超记忆或记忆状态的自我监控对于战略性信息使用至关重要.
- 超记忆背后的神经机制,特别是对于时间上不同的记忆, 仍然在很大程度上是未知的.
研究的目的:
- 研究灵长类动物中超记忆的因果神经机制.
- 识别与远程记忆相关的不同脑区.
主要方法:
- 用功能性磁共振成像 (fMRI) 来对子进行全脑检查.
- 使用可逆无活化技术来评估已识别的大脑区域的因果作用.
主要成果:
- 在前额区域9 (9/46d) 发现了远程事件的神经相关性.
- 一个不同的区域,区域6,被确定为最近事件的元记忆.
- 这些区域的非激活会选择性地损害元认知判断,而不会影响识别性能.
结论:
- 存在并行元记忆流,专门监督最近和远程记忆的识别网络.
- 这些发现突出了不同记忆时间尺度的元记忆的神经基础的解离.
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