休息时桃体活动与心血管事件之间的关系:纵向和队列研究
Ahmed Tawakol1, Amorina Ishai2, Richard Ap Takx2
1Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
高桃体活动,与压力相关的大脑区域,预测心血管疾病的风险更高. 这种联系是由骨髓活动和动脉炎症增加的, 提供了有关压力心脏病机制的新见解.
科学领域:
- 神经科学
- 心脏病学
- 医学成像
背景情况:
- 情绪压力是已知的心血管疾病 (CVD) 的危险因素.
- 桃体是处理压力的关键大脑区域, 研究其对心血管疾病风险的作用.
- 之前的研究没有直接将杏仁体的代谢活动与未来的心血管事件联系起来.
研究的目的:
- 确定休息时桃体代谢活动是否预测随后心血管疾病事件的风险.
- 探索感知到的压力,杏仁体活动,动脉炎症和C反应蛋白之间的关系.
- 阐明桃体活动和心血管疾病事件之间的中间途径,如果有的话.
主要方法:
- 在293名没有心血管疾病或癌症的患者 (年龄≥30岁) 进行长度研究,这些患者接受了18F-氧葡萄糖PET/CT.
- 使用经过验证的成像方法评估桃体活动,骨髓活动和动脉炎症.
- 统计分析包括考克斯模型,日志等级测试和调解分析,以评估桃体活动和心血管疾病事件之间的关系.
主要成果:
- 即使在调整后,桃体活动的增加也与心血管疾病事件的更高风险相关 (HR 1. 59, p< 0. 0001).
- 桃体活动与骨髓活动增加 (r=0. 47) 和动脉炎症 (r=0. 49) 相相关.
- 杏仁活动与心血管疾病事件之间的联系似乎是由骨髓活动和动脉炎症介导的.
结论:
- 休息桃体活动是未来心血管疾病事件的独立和强有力的预测因素.
- 从桃体活动到心血管疾病的途径包括骨髓活动增加和动脉炎症.
- 这些发现为人们的情绪压力如何导致心血管疾病提供了新的机械洞察力.
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