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IL-17是Caenorhabditis elegans感官反应的神经调节剂

Changchun Chen¹, Eisuke Itakura¹, Geoffrey M Nelson¹

¹MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

|January 19, 2017

概括

介质蛋白-17 (IL-17) 在神经系统中充当神经调节剂,直接影响神经元功能和行为. 这项研究揭示了IL-17

科学领域:

神经科学
免疫学
分子生物学

背景情况:

互白素-17 (IL-17) 是一种关键的促炎细胞因子,参与病原体反应,组织损伤和自身免疫性疾病.
在神经系统中IL-17的作用仍然在很大程度上未被探索.

研究的目的:

研究IL-17在神经系统中的神经调节功能.
识别IL-17信号通路及其行为中的细胞点.

主要方法:

在*Caenorhabditis elegans*中使用无偏的基因查来识别IL-17信号通路的组成部分.
研究了IL-17信号对神经元反应特性和动物行为的影响,特别是对氧气水平的反应.
使用光遗传学来操纵神经元活动并评估IL-17突变表型的救援.

主要成果:

证明IL-17具有类似神经调节器的特性,直接影响C. elegans的神经元功能和行为.
确定RMG枢纽内部神经元作为IL-17信号活动的部位.
破坏IL-17信号损害了RMG神经元对氧气传感器的响应,影响了逃生行为;相反,过度激活增加了反应.
通过光遗传刺激RMG神经元或通过诱导成年虫的IL-17表达来挽救IL-17缺乏.

结论:

揭示了IL-17在调节神经电路功能和行为的非免疫作用.
通过特定的神经元来确定IL-17是感官驱动行为的关键调节者.

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