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将单细胞基因组学从现象学扩展到机制

Amos Tanay^1,2, Aviv Regev^3,4,5

¹Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel.

|January 20, 2017

概括

单细胞基因组学揭示了组织中的细胞多样性,为细胞的发展和功能提供了新的见解. 需要进一步整合计算和实验方法来理解组织动态和基因调节.

科学领域:

* 发育生物学
* 基因组学
* 系统生物学

背景情况:

* 基本的生物学问题涉及细胞分化,组织功能和基因调节.
* 多细胞系统需要协调和灵活的组织功能.
了解基因调节机制对于这些过程至关重要.

研究的目的:

探索单细胞基因组学如何解决生物学中的基本问题.
* 研究单细胞基因组学在理解复杂的多细胞系统方面的潜力.
确定将基因组学与理论和计算框架相结合的挑战和未来方向.

主要方法:

使用单细胞基因组学来实现细胞状态的高分辨率分析.
* 将综合基因组数据与显微分辨率相结合.
* 整合理论,计算和实验框架.

主要成果:

单细胞基因组研究揭示了细胞状态的丰富多样性.
* 基因组学提供了一种全面的方法来研究细胞异质性.
* 单细胞基因组学的观察数据提供了对组织复杂性的洞察力.

结论:

单细胞基因组学是剖析细胞分化和组织的强大工具.
* 将观察性基因组数据转化为动态和因果模型具有重大挑战.
* 加强理论,计算和实验方法的整合对于该领域的发展至关重要.

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