Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Morphogenesis02:19

Morphogenesis

30.6K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.6K
Forced Transdifferentiation01:28

Forced Transdifferentiation

2.4K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
2.4K
Gastrulation01:56

Gastrulation

68.3K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.3K
Cellular Differentiation00:57

Cellular Differentiation

6.0K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
6.0K
Cell Migration01:19

Cell Migration

7.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.1K
Cell Migration01:09

Cell Migration

19.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
19.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia.

Communications biology·2026
Same author

Optogenetic mediated contractility enables reversible control of microglial morphology and migration in vivo.

Cell reports·2026
Same author

Developing evidence-based, cost-effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities.

Molecular oncology·2025
Same author

In toto analysis of embryonic organisation reduces tissue diversity to two archetypes requiring specific cadherins.

Nature communications·2025
Same author

Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation.

Nature communications·2025
Same author

Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early <i>Drosophila</i> embryo.

eLife·2024
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
查看所有相关文章

相关实验视频

Updated: Mar 8, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.7K

从形态生成到形态生成,然后又回来

Darren Gilmour1, Martina Rembold2,3, Maria Leptin1,2

  • 1European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Nature
|January 20, 2017
PubMed
概括
此摘要是机器生成的。

科学家们正在发现基因组如何通过将细胞命运的基因控制与细胞机械联系起来来决定生物的形状. 这项研究弥合了基因型-表型差距,促进了对强大的器官组装和组织工程的理解.

更多相关视频

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

11.9K
Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.4K

相关实验视频

Last Updated: Mar 8, 2026

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

11.7K
Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

11.9K
Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.4K

科学领域:

  • 发育生物学
  • 基因组学
  • 生物物理

背景情况:

  • 了解基因组在生物体形状中的作用是生命科学中的一个关键目标.
  • 弥合基因型和表型之间的差距需要将细胞命运的遗传控制与细胞形状生成机制联系起来.

研究的目的:

  • 确定控制细胞命运的基因与细胞机器生成形状之间的机制联系.
  • 阐明整合不同层次的形状控制的逻辑和机制.
  • 提供基于对形态发生的全面理解的组织工程框架.

主要方法:

  • 研究细胞命运决定的遗传控制.
  • 分析产生生物形状的细胞机器.
  • 研究器官组装中的交叉交谈和反机制.

主要成果:

  • 正在确定基因与细胞形状生成之间的机制联系.
  • 整合逻辑和形状控制机制正在出现.
  • 交叉通话和反机制有助于器官组装的稳定性.

结论:

  • 一个"完整的循环"理解形态发生正在出现.
  • 这种理解解决了生物学中的一个关键难题.
  • 这些发现为未来的组织工程方法提供了框架.