多孔 [PdnL4]2n+ 有不同客人的控制隔离绑定
Dan Preston1, James E M Lewis1, James D Crowley1
1Department of Chemistry, University of Otago , P.O. Box 56, Dunedin, New Zealand.
Journal of the American Chemical Society
|January 24, 2017
概括
研究人员开发了能够在不同的内部腔内选择性地结合不同分子的多腔金属超分子. 这一突破使得我们能够精确控制复杂结构中的分子相互作用.
科学领域:
- 超分子化学
- 协调化学
- 材料科学
背景情况:
- 金属上分子提供可调节的分子识别特性.
- 增加子的复杂性,例如多孔设计,在不失去特异性的情况下具有挑战性.
- 之前的小腔组件显示了结合特异性.
研究的目的:
- 合成和表征新的双和三腔金属超分子.
- 调查这些多孔的选择性结合能力.
- 在单个金属超分子结构中展示同步和分离的客结合.
主要方法:
- 聚和离子的合成.
- 形成 [Pd3(L) ]6+双腔和 [Pd4 ((L) ]4+三腔.
- 使用NMR光谱学,质谱学,元素分析和X射线晶体学进行表征.
- 用西斯普拉丁和三酸结合的研究.
主要成果:
- 成功合成了两个双腔体和一个三腔体的二.
- 已证明 cisplatin 在周围腔和三角形的外形面上具有选择性结合.
- 通过同时添加西斯普拉丁和三酸盐来实现同步和分离的客体结合.
结论:
- 开发了第一个离散的金属超分子架构,在设计的内部空洞中分离客体结合.
- 多孔为复杂的分子识别和封装提供了一个平台.
- 设计允许精确控制客人在子结构中的位置.
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