疟原虫和P. ovale基因组为疟原虫的进化提供了洞察力
Gavin G Rutledge1, Ulrike Böhme1, Mandy Sanders1
1Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Nature
|January 25, 2017
概括
对于Plasmodium malariae和Plasmodium ovale物种的遗传数据是有限的,阻碍了进化研究. 新的基因组数据澄清了它们与宿主之间的关系和进化适应性.
科学领域:
- 基因组学
- 进化生物学
- 寄生虫学
背景情况:
- 对Plasmodium malariae和Plasmodium ovale物种 (P. o. curtisi,P. o. wallikeri) 的有限遗传信息阻碍了对它们的进化历史和与其他感染人类的Plasmodium寄生虫的关系的理解.
- 这些引起疟疾的物种广泛存在,
研究的目的:
- 建立P. malariae和P. ovale在Plasmodium属中的进化关系.
- 研究这些Plasmodium物种的进化适应性和宿主转换能力.
主要方法:
- 一个新的P. malariae基因组的测序和分析.
- 手动策划和分析P.O. curtisi的基因组草案.
- 比较基因组学和分子年代分析.
主要成果:
- 在Plasmodium属内准确地定位P. malariae和P. o. curtisi.
- 在P. malariae和双宿主Plasmodium血统中发现类似的选择特征,表明并行宿主适应.
- 分子约会表明宿主适应的融合进化时间尺度.
- 发现一种可能参与红细胞入侵的P. malariae表面蛋白家族.
结论:
- 这项研究提供了对Plasmodium物种,特别是P. malariae和P. ovale进化的关键基因组见解.
- 对于疟疾控制和根除工作来说,了解宿主适应的遗传基础至关重要.
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