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Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters
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跨物种器官生成自主功能小岛

Tomoyuki Yamaguchi1, Hideyuki Sato1, Megumi Kato-Itoh1

  • 1Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.

Nature
|January 25, 2017
PubMed
概括

研究人员从老鼠的干细胞中制造出大小像老鼠一样的胰腺. 移植的小岛在糖尿病小鼠中使血糖正常化超过一年,显示出治疗糖尿病的潜力.

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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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