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在TGF-β的激活中与宏分子结构相互作用

Xianchi Dong1, Bo Zhao1, Roxana E Iacob2

  • 1Children's Hospital Boston and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|January 25, 2017
PubMed
概括

像αVβ6这样的整体因结合并对pro-TGF-β1施加力而重塑细胞外基质. 这种结合稳定了特定的方向,使增长因子释放的力传递成为可能.

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