马振荡组织向下垂体传递信号,使得它能够寻找食物
Marta Carus-Cadavieco1, Maria Gorbati1, Li Ye2,3
1Behavioural Neurodynamics Group, Leibniz Institute for Molecular Pharmacology (FMP)/ NeuroCure Cluster of Excellence, Berlin, Germany.
Nature
|February 2, 2017
概括
在大脑中协调的马振荡组织了小鼠寻找食物的行为. 通过同步的神经活动来调节饮食,
科学领域:
- 神经科学
- 行为神经科学
- 计算神经科学
背景情况:
- 动物和人类无论生理需求如何,都会追求奖励,以食物寻找行为脱离代谢需求为例.
- 这种分离是饮食障碍的一个挑战性症状,强调需要了解饮食的认知调节.
- 下丘脑和侧隔膜是养的关键, 接收来自皮质网络的输入, 但认知控制机制尚不清楚.
研究的目的:
- 研究食物寻找行为的认知调节的神经机制.
- 确定马振荡在组织养相关行动中的作用.
- 确定在养过程中控制下丘脑活动的上下路径.
主要方法:
- 在小鼠的横向下丘脑和上游区域的马振荡 (30-90 Hz) 的电生理记录.
- 侧面隔膜和中部前额皮层活动的光遗传学操纵.
- 对寻找食物和摄入食物任务的行为分析.
主要成果:
- 侧向下丘脑和上游区域的协调性马振荡组织了寻找食物的行为.
- 来自体质素阳性侧隔膜细胞的马节律输入促进食物接近,而不是摄入.
- 中间前额皮层向侧面隔膜投射提供了马节奏输入,因果关系与改善的食物奖励学习有关.
结论:
- 一个利用马同步的上下途径通过动态重组下丘脑神经元活动来调节养行为.
- 这一途径指导皮质下网络活动,提供了对食的认知控制的潜在机制.
- 这些发现为寻求回报的神经基础及其在饮食障碍中的失调提供了洞察力.
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