相关实验视频
Updated: Mar 8, 2026

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
1.3K
在类风湿性关节炎中,病理扩张的外围T辅助细胞子集驱动B细胞
Deepak A Rao1, Michael F Gurish1, Jennifer L Marshall2
1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature
|February 3, 2017
概括
研究人员在类风湿性关节炎患者中发现了一种新型的CD4+T细胞,称为外围辅助T细胞 (TPH). 这些TPH细胞在炎症组织中促进B细胞抗体的产生.
科学领域:
- 免疫学
- 关节病学
- 细胞生物学
背景情况:
- CD4+ T细胞是诸如类风湿性关节炎之类的自身免疫性疾病的关键.
- 很难确定病原性T细胞在组织中的特定效应器功能.
- 最近激活的标记可以帮助识别受影响组织中的致病性CD4+T细胞.
研究的目的:
- 在类风湿性关节炎中识别和表征致病性CD4+T细胞.
- 在类风湿关节炎关节组织中定义激活的T细胞的效应器功能.
- 研究PD-1hiCXCR5-CD4+T细胞在自身免疫病理中的作用.
主要方法:
- 用量细胞计和多维细胞计分析了类风湿性关节炎患者的T细胞.
- 进行了转录组分析,以比较不同的T细胞群.
- 使用体外功能测试来评估B细胞的辅助能力.
主要成果:
- 在类风湿性关节炎结膜中扩展了一种不同的PD-1hi-CXCR5-CD4+ T细胞群,称为TPH细胞.
- TPH细胞表达IL-21,CXCL13,ICOS和MAF等因素,使B细胞的帮助成为可能.
- 与T毛囊辅助细胞相比,转录组学揭示了TPH细胞的独特表达特征,包括炎症部位迁移的化学因子受体.
- 在体外,TPH细胞促进血细胞的分化和抗体的产生.
结论:
- PD-1hiCXCR5-TPH细胞是一种独特的CD4+T细胞子集,在类风湿性关节炎中扩大.
- 在炎症的非淋巴细胞组织中,TPH细胞能够促进B细胞反应和抗体的产生.
- 这些发现为推动类风湿性关节炎发病的细胞机制提供了新的见解.
相关概念视频
T Cell Types and Functions
3.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.0K
B Cell Activation and Differentiation
17.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.6K
Autoimmune Disorders
2.0K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.0K
Cells of the Adaptive Immune Response
9.6K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.6K
T Cell Activation and Clonal Selection
16.9K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
16.9K
The JAK-STAT Signaling Pathway
13.5K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
13.5K

