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DNA-PKcs结构表明一种调节DNA双链断裂的异质机制

Bancinyane L Sibanda1, Dimitri Y Chirgadze1, David B Ascher1

  • 1Department of Biochemistry, University of Cambridge, Old Addenbrooke's Site, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

Science (New York, N.Y.)
|February 4, 2017
PubMed
概括

DNA依赖蛋白激酶催化子单位 (DNA-PKcs) 修复DNA双链断裂. 它的结构揭示了基激活机制和与BRCA1的竞争,影响了DNA修复途径的选择.

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