下垂体腺瘤的诊断和治疗:一篇综述
1Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
JAMA
|February 8, 2017
概括
早期诊断下垂体腺瘤对于有效治疗至关重要. 通常使用多巴胺激动剂治疗乳腺瘤,而其他腺瘤通常需要手术.
科学领域:
- 内分泌学
- 神经外科
- 癌症学
背景情况:
- 下垂体腺瘤是常见的瘤,患病率不同.
- 它们会导致荷尔蒙过分分泌或质量效应,影响健康.
- 早期发现和治疗对于患者的结果至关重要.
研究的目的:
- 总结各种垂体腺瘤的诊断和治疗方法.
- 强调早期发现和干预的重要性.
- 根据腺瘤类型概述当前的治疗策略.
主要方法:
- 对垂体腺瘤的流行,类型和临床表现的审查.
- 诊断方法的描述,包括激素水平测量和成像.
- 治疗方法的总结:手术,医疗疗法和放射治疗.
主要成果:
- 用多巴胺激动剂治疗乳腺瘤 (32-66%).
- 最初使用手术治疗的GH分泌瘤 (8- 16%),通常需要医疗治疗.
- 通过手术和治疗库辛病的药物来治疗分泌ACTH的瘤 (2-6%).
- 非功能性腺瘤 (15-54%) 通常需要手术来进行质量效应.
结论:
- 早期诊断下垂体腺瘤可以有效治疗.
- 多巴胺激动剂是前乳腺瘤的主要治疗方法.
- 对于大多数其他垂体腺瘤来说,跨形外科手术是最初的治疗方法,医疗选择只适用于没有反应的患者.
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