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用于早期发现癌症的循环瘤DNA的下一代测序

Alexander M Aravanis¹, Mark Lee¹, Richard D Klausner¹

¹GRAIL, Menlo Park, CA 94402, USA.

|February 11, 2017

概括

早期发现癌症有助于治疗成功. 循环瘤DNA的下一代测序为开发安全有效的癌症查测试提供了有前途的方法.

科学领域:

癌症学
分子生物学
生物技术

背景情况:

癌症的早期诊断对于成功治疗至关重要.
目前的癌症查方法在安全性和有效性方面面临挑战.
循环中的瘤衍生核酸是潜在的生物标志物来源.

研究的目的:

支持下一代测序技术的发展.
突出瘤衍生核酸在癌症查中的潜力.

主要方法:

下一代测序 (NGS) 技术
分析循环中的瘤衍生核酸 (ctDNA).

主要成果:

对于早期癌症检测而言, ctDNA 的 NGS 是有前途的.
技术进步是开发有效查测试的关键.

结论:

下一代ctDNA测序是一种有前途的癌症早期检测策略.
这一领域的进一步发展可以带来更安全,更有效的癌症查测试.

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相关概念视频

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.