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扩张性心肌病
Robert G Weintraub1, Christopher Semsarian2, Peter Macdonald3
1Department of Cardiology, Royal Children's Hospital, Melbourne, VIC, Australia; Murdoch Children's Research Institute, Melbourne, VIC, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
Lancet (London, England)
|February 14, 2017
概括
扩张性心肌病涉及左心室膨胀和动功能不佳,通常是由遗传或遗传因素引起的. 治疗重点是控制心力衰竭的症状,防止突然死亡.
科学领域:
- 心脏病学
- 遗传学
- 内部医学
背景情况:
- 扩张性心肌病 (DCM) 的特征是左心室扩大和收缩能力受损.
- 遗传突变 (细胞骨,,核包膜蛋白) 导致多达35%的DCM病例.
- 获得的原因包括心肌炎,毒素和代谢/内分泌问题.
研究的目的:
- 定义扩张性心肌病并概述其原因,症状和当前的治疗策略.
- 突出DCM的预后因素和新兴的治疗研究.
主要方法:
- 对扩张性心肌病的现有文献的审查.
- 对遗传和获得病因的分析.
- 临床表现,诊断指标和治疗干预措施的总结.
主要成果:
- DCM表现为充血性心力衰竭,心律失常或循环崩的症状.
- 预后与排泄分数和腹功能障碍的严重程度有关.
- 慢性心力衰竭的标准治疗包括ACE抑制剂和β抑制剂.
结论:
- 扩张性心肌病的有效治疗包括治疗心力衰竭,心律失常和突然死亡风险.
- 多学科护理,设备治疗和先进的治疗方法如机械支持或移植对于耐火病例至关重要.
- 目前正在进行的研究正在探索临床前疾病治疗和干细胞治疗的潜在作用.
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