使用基作为碳素前体的催化B-H键插入反应
Ji-Min Yang1, Zi-Qi Li1, Mao-Lin Li1
1State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, China.
Journal of the American Chemical Society
|February 15, 2017
概括
过渡金属催化剂使添加物和之间的B-H键插入反应能够产生有机化合物. 这种新的方法提供了高产量,原子经济,以及对化的不对称途径.
科学领域:
- 有机金属化学
- 有机合成
- 催化剂
背景情况:
- 过渡金属催化对于开发新型合成方法至关重要.
- 有机化合物是有机合成中的多功能中间体.
- 对于B-H键功能化的有效方法非常受欢迎.
研究的目的:
- 报告一种新型的过渡金属催化B-H键插入反应.
- 开发一种非对称的催化系统,用于合成性有机化合物.
- 调查反应机制和动力学.
主要方法:
- 使用过渡金属 (例如铜,二复合物) 的催化.
- 在温和条件下,添加物与的反应.
- 不对称的催化,使用性复合物.
- 动力学研究和密度函数理论 (DFT) 的计算.
主要成果:
- 有机化合物合成的优异产量.
- 实现了100%的原子经济.
- 在性酸的不对称合成中具有很高的反选择性 (高达96% ee).
- 已证实可轻易地将奇拉转化为酸盐和二甲醇化合物,而不会损失光学纯度.
- 动力学表明Cu碳素形成是Cu催化反应的速度限制步骤.
结论:
- 通过B-H键插入建立了一个新的,高效和原子经济的途径来获得有机化合物.
- 一个高度选的非对称的催化系统的发展扩大了这种反应在合成性分子的实用性.
- 机械学的见解为进一步优化和在有机合成中应用这种方法提供了基础.
相关概念视频
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02:38Electrophilic Addition to Alkynes: Halogenation
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02:34Preparation of Alkynes: Dehydrohalogenation
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