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相关概念视频

Symbiosis00:58

Symbiosis

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Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
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Diversity of Protists II01:27

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Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
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相关实验视频

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Generating Genetically Modified Plasmodium berghei Sporozoites
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通过化疗减弱的PfSPZ疫苗对人类疟疾进行无菌保护

Benjamin Mordmüller1, Güzin Surat1, Heimo Lagler1,2

  • 1Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen, 72074 Tübingen, Germany.

Nature
|February 16, 2017
PubMed
概括
此摘要是机器生成的。

一种新的疟疾疫苗PfSPZ-CVac在临床试验中显示出100%的抗疟疾保护. 这种候选疫苗具有很高的疗效,可能是消除疟疾策略的关键.

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Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
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High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
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相关实验视频

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High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
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High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

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科学领域:

  • 免疫学
  • 疫苗学
  • 传染性疾病

背景情况:

  • 高度保护性疟疾疫苗对于预防和制耐药寄生虫至关重要.
  • 之前的高效疟疾疫苗使用了辐射减弱的Plasmodium falciparum杂虫 (PfSPZ).

研究的目的:

  • 评估一种新的疟疾疫苗方法PfSPZ-CVac的安全性和有效性,使用化学预防的非辐射PfSPZ的直接静脉注射.
  • 确定PfSPZ-CVac的最佳剂量和治疗方案.

主要方法:

  • 通过直接静脉接种,健康的未患疟疾的成年志愿者接受了三剂PfSPZ- CVac.
  • 志愿者接受了用于抗疟疾化学预防的.
  • 使用受控的人类疟疾感染来评估疫苗接种后的保护效果.

主要成果:

  • 在9/9名志愿者中,三剂5. 12×104PfSPZ被很好地耐受和安全,达到100%的保护.
  • 较低的剂量 (3. 2 × 103 或 1. 28 × 104 PfSPZ) 分别为33%和67%的保护.
  • 与保护相关的Pf特异性多功能CD4记忆T细胞的发生频率.

结论:

  • PfSPZ-CVac是一种高效的疟疾疫苗候选剂.
  • 优化疫苗接种方案可能会使其用于消除疟疾的大规模疫苗接种计划.
  • 这种方法有望控制疟疾, 尤其是耐药菌株.