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通过化疗减弱的PfSPZ疫苗对人类疟疾进行无菌保护
Benjamin Mordmüller1, Güzin Surat1, Heimo Lagler1,2
1Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen, 72074 Tübingen, Germany.
Nature
|February 16, 2017
概括
一种新的疟疾疫苗PfSPZ-CVac在临床试验中显示出100%的抗疟疾保护. 这种候选疫苗具有很高的疗效,可能是消除疟疾策略的关键.
科学领域:
- 免疫学
- 疫苗学
- 传染性疾病
背景情况:
- 高度保护性疟疾疫苗对于预防和制耐药寄生虫至关重要.
- 之前的高效疟疾疫苗使用了辐射减弱的Plasmodium falciparum杂虫 (PfSPZ).
研究的目的:
- 评估一种新的疟疾疫苗方法PfSPZ-CVac的安全性和有效性,使用化学预防的非辐射PfSPZ的直接静脉注射.
- 确定PfSPZ-CVac的最佳剂量和治疗方案.
主要方法:
- 通过直接静脉接种,健康的未患疟疾的成年志愿者接受了三剂PfSPZ- CVac.
- 志愿者接受了用于抗疟疾化学预防的.
- 使用受控的人类疟疾感染来评估疫苗接种后的保护效果.
主要成果:
- 在9/9名志愿者中,三剂5. 12×104PfSPZ被很好地耐受和安全,达到100%的保护.
- 较低的剂量 (3. 2 × 103 或 1. 28 × 104 PfSPZ) 分别为33%和67%的保护.
- 与保护相关的Pf特异性多功能CD4记忆T细胞的发生频率.
结论:
- PfSPZ-CVac是一种高效的疟疾疫苗候选剂.
- 优化疫苗接种方案可能会使其用于消除疟疾的大规模疫苗接种计划.
- 这种方法有望控制疟疾, 尤其是耐药菌株.
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