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Updated: Mar 7, 2026

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KICSTOR将GATOR1招募到溶酶体中,并且对于营养素来调节mTORC1是必要的

Rachel L Wolfson1,2,3,4, Lynne Chantranupong1,2,3,4, Gregory A Wyant1,2,3,4

  • 1Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Nature
|February 16, 2017
PubMed
概括

一个新发现的KICSTOR蛋白质复合体负面调节了RAPAMYCIN复合体1 (mTORC1) 信号传递的机械标. 这种复合物对于抑制mTORC1的反应至关重要,其功能障碍与神经疾病有关.

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