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Updated: Mar 7, 2026

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Published on: September 20, 2017

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酸丁醇3酶阻断增加了B细胞中的基因组不稳定性

Mara Compagno1, Qi Wang1, Chiara Pighi1

  • 1Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|February 16, 2017
PubMed
概括

针对PI3Kδ途径的某些白血病和淋巴瘤药物通过增强激活诱导的cytidine deaminase (AID) 表达来增加B细胞的基因组不稳定性. 这种依赖于AID的机制增加了突变和转移的频率,可能会影响患者的长期安全.

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