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胰腺神经内分泌瘤的全基因组景观

Aldo Scarpa1,2, David K Chang3,4,5,6,7, Katia Nones8,9

  • 1ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona 37134, Italy.

Nature
|February 16, 2017
PubMed
概括

胰腺神经内分泌瘤 (PanNETs) 的基因组分析揭示了MUTYH,CHEK2和BRCA2等DNA修复基因的频繁基因突变. 这些发现对于理解PanNET病变和改善临床管理至关重要.

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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