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SZT2 指令GATOR控制mTORC1的信号

Min Peng1, Na Yin1, Ming O Li1

  • 1Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

Nature
|February 16, 2017
PubMed
概括

抓获值2 (SZT2) 蛋白与GATOR1和GATOR2形成复合体,这对于通过mTORC1信号传递来感知和控制细胞生长至关重要. SZT2 缺乏破坏了这一过程,导致小鼠细胞功能障碍和新生儿死亡.

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