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抑郁症治疗和急性心肌梗塞后的一年死亡率:TRIUMPH注册表的见解 (研究急性心肌梗塞患者健康状况的基础差异的翻译研究)

Kim G Smolderen1, Donna M Buchanan2, Kensey Gosch2

  • 1From Saint Luke's Mid America Heart Institute, Kansas City, MO (K.G.S., D.M.B., K.G., P.S.C., J.A.S.); University of Missouri, Kansas City (K.G.S., D.M.B., P.S.C., J.A.S.); University of California, Department of Veterans Affairs Medical Center, San Francisco (M.W.); Rollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA (V.V., A.J.S.); Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA (V.V., A.J.S.); Atlanta Veterans Affairs Medical Center, GA (A.J.S.); and Denver Veterans Affairs Medical Center, CO (P.M.H.). smolderenk@umkc.edu.

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|February 18, 2017
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概括
此摘要是机器生成的。

在急性心肌梗塞 (AMI) 患者中治疗抑郁症不会显著改变死亡率. 然而,AMI患者未经治疗的抑郁症与一年死亡率的增加有关,这突显了干预的重要性.

关键词:
抑郁症死亡率心肌梗塞生存时间

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科学领域:

  • 心脏病学
  • 精神病学
  • 公共卫生

背景情况:

  • 抑郁症在急性心肌梗塞 (AMI) 患者中很常见,对生活质量和预后产生负面影响.
  • 目前的指导方针建议对抑郁症进行查,但治疗对AMI患者的结果的影响尚不清楚.

研究的目的:

  • 调查治疗和未治疗抑郁症与AMI患者的预后之间的关联.
  • 在没有抑郁症,接受治疗的抑郁症和未接受治疗的抑郁症患者中比较一年死亡率.

主要方法:

  • 在TRIUMPH研究中,从24家美国医院招募了4062名AMI患者 (2005 - 2008年).
  • 使用患者健康问卷-9 (PHQ-9) 评分 (≥10) 确定抑郁症.
  • 患者被分为经过治疗的抑郁症 (已有诊断,药物或咨询转诊) 或未经治疗的抑郁症.

主要成果:

  • 18. 7% 的患者 (759) 患有抑郁症,其中 30. 4% (231) 接受治疗.
  • 与没有抑郁症的患者相比,接受治疗的抑郁症患者在一年内死亡率没有显著差异 (6. 7% 和 6. 1%).
  • 未接受治疗的抑郁症患者在一年内死亡率明显高于没有抑郁症患者 (10. 8% vs 6. 1%).

结论:

  • 在AMI患者中,抑郁症与长期死亡率的增加有关.
  • 这种增加的死亡风险似乎主要与未经治疗的抑郁症有关.