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Updated: Aug 16, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Published on: February 28, 2019

在HLA转基因小鼠中对病毒抗原的HLA受限识别

F Kievits1, P Ivanyi, P Krimpenfort

  • 1Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Immunochematology, University of Amsterdam, The Netherlands.

Nature
|October 1, 1987
PubMed
概括

鼠标T细胞受体可以识别人类MHC分子. 这表明T细胞受体库可能不是严格的物种特异性,影响物种间的免疫识别.

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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.