通过介质素-1直接作用于垂体细胞,释放多种激素
E W Bernton1, J E Beach, J W Holaday
1Division of Neuropsychiatry, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.
概括
介素-1 (IL-1) 直接影响前垂体腺体激素分泌. 这种免疫信号分子刺激了ACTH和TSH等关键激素,同时抑制了益生菌素,影响了对感染的代谢反应.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 细菌内毒素刺激前垂体激素的释放,历史上用于测试垂体功能.
- 内毒素诱导介质素-1 (IL-1),这是由巨细胞和单细胞产生的 pyrogenic 蛋白质.
- 对于IL-1对 pituitary激素分泌的直接作用需要进一步研究.
研究的目的:
- 在实验室中研究介质素-1 (IL-1) 对大鼠前垂体细胞激素分泌的直接作用.
- 确定受IL-1影响的特定垂体激素和度依赖的反应.
主要方法:
- 在单层培养中利用了老鼠垂体细胞.
- 在一系列度范围内 (10^-9M到10^-12M) 给予重组人体IL-1β.
- 测量了培养超级生物中的激素水平,并评估了IL-1抗体中和的影响.
主要成果:
- IL-1β显著刺激了上腺皮质激素 (ACTH),黄素激素 (LH),生长激素 (GH) 和甲状腺刺激激素 (TSH) 的分泌.
- 通过类似的IL-1度抑制了前素分泌.
- 观察到的效应被IL-1的抗体中和,证实了特异性.
结论:
- 介质素-1 (IL-1) 在体外直接调节前垂体激素分泌.
- 在感染或压力条件下,IL-1可能充当代谢适应的关键调节者.
- 来自免疫细胞的外周IL-1信号可能会在体内影响垂体激素的释放.
相关概念视频
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