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通过CRISPR/Cas9将CAR向TRAC位点,可以增强瘤排斥

Justin Eyquem1, Jorge Mansilla-Soto1, Theodoros Giavridis1

  • 1Center for Cell Engineering and Immunology Program, Sloan Kettering Institute, New York, New York 10065, USA.

Nature
|February 23, 2017
PubMed
概括

通过CRISPR/Cas9基因组编辑,可以精确地将仿真抗原受体 (CAR) 传递到TRAC位点,从而增强T细胞的功效,并改善B细胞恶性瘤的结果.

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