首先出现的是病毒还是卵子?
1The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell
|February 25, 2017
概括
三项研究表明,HAP2蛋白是细胞融合的关键. 这种蛋白质在结构上与病毒融合蛋白质相似,表明细胞-细胞和病毒-细胞融合机制的共同进化起源.
科学领域:
- 细胞生物学
- 病毒学
- 遗传学
背景情况:
- 细胞融合是生殖和发育所必需的基本生物过程.
- 病毒融合蛋白调解病毒进入宿主细胞.
- 基质融合的分子机制仍然不完全理解.
研究的目的:
- 调查参与性质融合的分子参与者.
- 确定配体融合蛋白与病毒融合蛋白之间的结构和功能关系.
主要方法:
- 基因组比较分析
- 蛋白质结构预测
- 配体融合的功能测试
主要成果:
- 单通膜蛋白HAP2被确定为配体融合的关键媒介.
- HAP2与病毒中发现的II类融合蛋白具有显著的结构同质性.
- 这种相似之处延伸到登革热和寨卡病毒等病毒.
结论:
- HAP2代表了一种介导膜融合事件的保存机制.
- 这些发现表明细胞和病毒膜融合机制的共同进化起源.
- HAP2可以作为生殖生物学和传染病治疗干预的目标.
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