在17年的随访后,一次性灵活西格莫多斯科比查的长期影响:英国灵活西格莫多斯科比查随机对照试验
Wendy Atkin1, Kate Wooldrage1, D Maxwell Parkin2
1Cancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London, London, UK.
一次灵活的西格莫镜查显著降低了结直肠癌的发病率和死亡率. 这种预防癌症诊断和死亡的方法在查后至少持续17年.
科学领域:
- 胃肠病学
- 癌症学
- 预防医学
背景情况:
- 结肠直肠癌是全球主要的恶性瘤.
- 之前的灵活西格莫镜查研究的随访时间有限 (最长为12年).
- 需要评估灵活的西格莫镜查的长期结果.
研究的目的:
- 评估结直肠癌的长期发病率和死亡率.
- 确定单个灵活的西格莫多斯科普查所提供的保护时间.
- 在17年的随访后分析结果.
主要方法:
- 一个多中心随机试验 (英国灵活的西格米多斯科普查试验) 涉及170,432名参与者.
- 参与者被随机分配到灵活的西格莫镜查或对照组.
- 用治疗意向和每项方案分析估计结直肠癌发病率和死亡率的危险比率.
主要成果:
- 查组与对照组的结直肠癌发病率降低了26% (HR 0. 74),死亡率降低了30% (HR 0. 70).
- 每项方案分析显示,查患者的发病率降低了35%,死亡率降低了41%.
- 这些益处在平均随访时间为17. 1年时被观察到.
结论:
- 一次灵活的西格莫镜查提供了对结直肠癌的显著和持久的保护.
- 对结直肠癌诊断和死亡的保护作用延长至至少17年.
- 灵活的半导体镜是长期预防结肠直肠癌的有效工具.
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