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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
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小分子抑制微RNA-210重新编程致癌性低毒循环

Matthew G Costales1, Christopher L Haga1, Sai Pradeep Velagapudi1

  • 1Department of Chemistry, ‡Department of Molecular Therapeutics, and §Department of Neuroscience, The Scripps Research Institute , 130 Scripps Way, Jupiter, Florida 33458, United States.

Journal of the American Chemical Society
|February 28, 2017
PubMed
概括

一种新的小分子Targapremir-210可以选择性地向microRNA-210 (miR-210) 前体. 这抑制了癌细胞的生长,并特别在缺氧三阴性乳腺癌中触发了细胞亡.

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