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Updated: Mar 7, 2026

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从双盲和开放扩展研究中对6000多名患者进行的evolocumab安全性分析

Peter P Toth1, Olivier Descamps2, Jacques Genest2

  • 1From CGH Medical Center, Sterling, IL, and Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (P.P.T.); Lipid Clinic, Centres Hospitaliers Jolimont, Haine-Saint-Paul, Belgium (O.D.); The McGill University Health Centre, Montreal, Canada (J.G.); Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK (N.S.); Medical Research Council Population Health Research Unit, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, UK (D.P.); and Amgen Inc, Thousand Oaks, CA (R.D., C.D., Y.W., M.G., M.U., R.S., S.M.W.). peter.toth@cghmc.com.

Circulation
|March 3, 2017
PubMed
概括

在临床试验中,Evolocumab是一种PCSK9抑制剂,与对照药物相比,其安全性和耐受性相似. 这项对6000多名患者的分析证实了该药物对胆固醇管理的有利利益风险概况.

关键词:
单克隆抗体胆固醇,LDL长期不良事件骨髓疼痛蛋白转化酶9

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