通过骨基利波卡林抑制食欲
Ioanna Mosialou1, Steven Shikhel1, Jian-Min Liu1
1Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Nature
|March 9, 2017
概括
骨通过增加胰岛素分泌来调节血糖的激素 - - 利波卡林2 (LCN2). 通过对大脑的作用, LCN2还抑制了食欲,
科学领域:
- 内分泌学
- 代谢研究
- 骨生物学
背景情况:
- 骨被认为是一种内分泌器官,分泌FGF23和骨素等激素.
- 现有研究强调骨在调节功能和葡萄糖平衡中的作用.
- 其他骨源激素的存在和功能在很大程度上仍未被探索.
研究的目的:
- 识别新的骨源激素并阐明它们的代谢功能.
- 调查卡林2 (LCN2) 作为潜在的骨源激素的作用.
- 确定 LCN2 影响葡萄糖平衡和食欲的机制.
主要方法:
- 在小鼠模型中进行分子和遗传分析.
- 功能损失和增益的实验,以评估LCN2的影响.
- 研究LCN2与下丘脑中的黑色皮质素4受体 (MC4R) 的相互作用.
主要成果:
- 利波卡林2 (LCN2) 是一种由骨质细胞丰富的分泌蛋白质.
- 通过诱导胰岛素分泌,提高胰岛素耐受性和胰岛素敏感性,骨质细胞衍生的LCN2可增强葡萄糖平衡.
- LCN2通过血脑屏障,与MC4R结合,并激活抑制食欲的途径.
结论:
- LCN2作为一种骨源激素,具有显著的代谢调节作用.
- 通过MC4R信号,骨质细胞衍生的LCN2在抑制食欲方面发挥着至关重要的作用.
- 胃口的内分泌调节被认为是骨的一个新功能.
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