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Updated: Mar 6, 2026

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

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通过基因组架构映射捕获的复杂多增强器接触

Robert A Beagrie1,2,3, Antonio Scialdone4, Markus Schueler1

  • 1Epigenetic Regulation and Chromatin Architecture Group, Berlin Institute for Medical Systems Biology, Max-Delbrück Centre for Molecular Medicine, Robert-Rössle Straße, Berlin-Buch 13125, Germany.

Nature
|March 9, 2017
PubMed
概括

基因组架构映射 (GAM) 揭示了基因和调控元素在核中的3D空间中如何相互作用. 这种新方法为基因组组织及其在基因表达中的作用提供了前所未有的洞察力.

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相关概念视频

DNA-only Transposons02:57

DNA-only Transposons

DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
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